When Mail.app has too many messages, it can take a few seconds to start. One great way to reduce this load time is by stripping out unnecessary information. Open Terminal.app and type the following command:
sqlite3 ~/Library/Mail/Envelope\ Index vacuum subjects;
To get out of the SQLite command interface, press 
To see how much space your saving, run the following command before and after:
ls -lah ~/Library/Mail/Envelope\ Index
You can also run the following command if you’d like to try and gain even more performance:
sqlite3 ~/Library/Mail/Envelope\ Index vacuum body;
Mail.app should now start much faster than it previously did.
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